.Pharmacolibrary.Drugs.ATC.N.N07XX59

Information

name:DextromethorphanCombinations
ATC code:N07XX59
route:oral
n-compartments2

Dextromethorphan, in combination drug formulations, is a non-opioid antitussive (cough suppressant) commonly used to reduce cough. Combinations can include various agents, such as antidepressants or other CNS-active drugs, and may be used for cough suppression or for research into central nervous system disorders. While dextromethorphan-containing combinations for cough are approved, combinations used for research in conditions like pseudobulbar affect (e.g., with quinidine) may have specific indications.

Pharmacokinetics

Estimated typical adult values for oral dosing based on known pharmacokinetic properties of dextromethorphan in combination products; no direct published studies report compartmental model parameters specifically for combinations assigned to N07XX59.

References

  1. Heinrich, N, et al., & Hoelscher, M (2025). Safety, bactericidal activity, and pharmacokinetics of the antituberculosis drug candidate BTZ-043 in South Africa (PanACEA-BTZ-043-02): an open-label, dose-expansion, randomised, controlled, phase 1b/2a trial. The Lancet. Microbe 6(2) 100952–None. DOI:10.1016/j.lanmic.2024.07.015 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39793592

  2. Walzer, M, et al., & Tolbert, D (2012). Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes. Pharmacotherapy 32(4) 340–353. DOI:10.1002/j.1875-9114.2012.01028.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/22422635

Revisions


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