.Pharmacolibrary.Drugs.ATC.P.P01AA02 .Pharmacolibrary.Drugs.ATC.P.P01AA02| name: | Clioquinol |
| ATC code: | P01AA02 | route: | oral |
| n-compartments | 1 |
Clioquinol is an antifungal and antiprotozoal medication from the hydroxyquinoline class, historically used for the treatment of intestinal amoebiasis, fungal skin infections, and as a topical agent. It was previously widely used, but oral use is now largely discontinued in many countries due to concerns about neurotoxicity (e.g., subacute myelo-optic neuropathy), though topical formulations may still be in limited use.
Estimated pharmacokinetic parameters for oral administration in adult humans, since no reliable recent primary clinical pharmacokinetic study could be identified.
Schimmer, AD, et al., & Minden, MD (2012). A phase I study of the metal ionophore clioquinol in patients with advanced hematologic malignancies. Clinical lymphoma, myeloma & leukemia 12(5) 330–336. DOI:10.1016/j.clml.2012.05.005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22683301