.Pharmacolibrary.Drugs.ATC.P.P01AX06

Information

name:Atovaquone
ATC code:P01AX06
route:oral
n-compartments2

Atovaquone is a hydroxynaphthoquinone antiprotozoal medication primarily used for the treatment and prevention of Pneumocystis jirovecii pneumonia (PCP), toxoplasmosis, and in combination with proguanil for malaria treatment and prophylaxis. It is approved for use in many countries.

Pharmacokinetics

Population pharmacokinetic model of atovaquone in healthy adult volunteers after oral administration.

References

  1. Hussein, Z, et al., & Canfield, CJ (1997). Population pharmacokinetics of atovaquone in patients with acute malaria caused by Plasmodium falciparum. Clinical pharmacology and therapeutics 61(5) 518–530. DOI:10.1016/S0009-9236(97)90132-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9164414

  2. Hussein, Z, et al., & Canfield, CJ (1996). Population pharmacokinetics of proguanil in patients with acute P. falciparum malaria after combined therapy with atovaquone. British journal of clinical pharmacology 42(5) 589–597. DOI:10.1111/j.1365-2125.1996.tb00114.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/8951190

  3. McGready, R, et al., & Nosten, F (2003). The pharmacokinetics of atovaquone and proguanil in pregnant women with acute falciparum malaria. European journal of clinical pharmacology 59(7) 545–552. DOI:10.1007/s00228-003-0652-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12955371

Revisions


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