.Pharmacolibrary.Drugs.ATC.P.P01BA03

Information

name:Primaquine
ATC code:P01BA03
route:oral
n-compartments1

Primaquine is an 8-aminoquinoline antimalarial drug primarily used for the radical cure of Plasmodium vivax and Plasmodium ovale malaria by eradicating hepatic hypnozoites. It is also indicated in the treatment and prevention of Pneumocystis jirovecii pneumonia. Primaquine is approved and in clinical use today for malaria treatment, especially for prevention of malaria relapses.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers taking oral primaquine, both sexes, median age around 25-35 years.

References

  1. Carag, JH, et al., & Bronson, E (2021). PHARMACOKINETICS OF PRIMAQUINE PHOSPHATE AFTER A SINGLE ORAL ADMINISTRATION TO AFRICAN PENGUINS (. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 52(1) 75–80. DOI:10.1638/2020-0172 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33827163

  2. Chairat, K, et al., & Tarning, J (2018). Enantiospecific pharmacokinetics and drug-drug interactions of primaquine and blood-stage antimalarial drugs. The Journal of antimicrobial chemotherapy 73(11) 3102–3113. DOI:10.1093/jac/dky297 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30085149

  3. Kulkarni, SP, et al., & Gogtay, NJ (2013). Pharmacokinetics of single-dose primaquine in patients with chronic kidney dysfunction. Indian journal of pharmacology 45(4) 330–333. DOI:10.4103/0253-7613.114997 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24014905

Revisions


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