.Pharmacolibrary.Drugs.ATC.P.P01BE01

Information

name:Artemisinin
ATC code:P01BE01
route:oral
n-compartments2

Artemisinin is a sesquiterpene lactone isolated from the plant Artemisia annua, used primarily as an antimalarial agent. It is effective against Plasmodium falciparum malaria and is used in combination therapies for treatment. Artemisinin and its derivatives are widely used and recommended by the World Health Organization (WHO) for malaria treatment.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers after single oral dosing.

References

  1. Sidhu, JS, et al., & Cong, LD (1998). Artemisinin population pharmacokinetics in children and adults with uncomplicated falciparum malaria. British journal of clinical pharmacology 45(4) 347–354. DOI:10.1046/j.1365-2125.1998.t01-1-00686.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/9578181

  2. Birgersson, S, et al., & Tarning, J (2016). Population pharmacokinetic properties of artemisinin in healthy male Vietnamese volunteers. Malaria journal 15 90–None. DOI:10.1186/s12936-016-1134-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26879816

  3. Svensson, US, et al., & Ashton, M (2002). Population pharmacokinetic and pharmacodynamic modelling of artemisinin and mefloquine enantiomers in patients with falciparum malaria. European journal of clinical pharmacology 58(5) 339–351. DOI:10.1007/s00228-002-0485-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/12185558

Revisions


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