.Pharmacolibrary.Drugs.ATC.P.P01BF01_1 .Pharmacolibrary.Drugs.ATC.P.P01BF01_1| name: | ArtemetherAndLumefantrine_1 | |
| ATC code: | P01BF01_1 | route: | oral |
| compartments: | 2 | |
| dosage: | 480 | mg |
| volume of distribution: | 1170 | L |
| clearance: | 34.8 | L/h |
| other parameters in model implementation | ||
Artemether and lumefantrine combination is an artemisinin-based antimalarial therapy (ACT) used for the treatment of uncomplicated Plasmodium falciparum malaria. It is a widely approved first-line treatment in many countries and is currently recommended by the World Health Organization for malaria therapy.
Pharmacokinetic parameters reported in healthy adult volunteers (non-pregnant, mixed sex, age ~18-45 years) after oral administration of standard dose for lumefantrine component.
Hietala, SF, et al., & Ashton, M (2010). Population pharmacokinetics and pharmacodynamics of artemether and lumefantrine during combination treatment in children with uncomplicated falciparum malaria in Tanzania. Antimicrobial agents and chemotherapy 54(11) 4780–4788. DOI:10.1128/AAC.00252-10 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20713675