.Pharmacolibrary.Drugs.ATC.P.P01BF03 .Pharmacolibrary.Drugs.ATC.P.P01BF03| name: | ArtesunateAndAmodiaquine | |
| ATC code: | P01BF03 | route: | oral |
| compartments: | 1 | |
| dosage: | 200 | mg |
| volume of distribution: | 147 | L |
| clearance: | 65 | L/h |
| other parameters in model implementation | ||
Artesunate and amodiaquine is a fixed-dose combination antimalarial drug, used primarily for the treatment of uncomplicated Plasmodium falciparum malaria. Artesunate is a fast-acting artemisinin derivative, while amodiaquine is a 4-aminoquinoline antimalarial. The combination is recommended by the WHO and is widely used and approved for first-line malaria treatment in endemic regions.
Pharmacokinetic parameters reported for healthy African adults (both genders), median age 24 years, following administration of oral fixed-dose artesunate-amodiaquine (200 mg artesunate + 540 mg amodiaquine) once daily for 3 days.