.Pharmacolibrary.Drugs.ATC.P.P01BF06 .Pharmacolibrary.Drugs.ATC.P.P01BF06| name: | ArtesunateAndPyronaridine | |
| ATC code: | P01BF06 | route: | oral |
| compartments: | 2 | |
| dosage: | 540 | mg |
| volume of distribution: | 141 | L |
| clearance: | 1.58 | L/h |
| other parameters in model implementation | ||
Artesunate and pyronaridine is a combination antimalarial therapy used for the treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax malaria. Artesunate is a fast-acting artemisinin derivative, while pyronaridine is a longer-acting component; together they provide rapid parasite clearance and prevent recrudescence. The combination is approved under the trade name Pyramax in several countries for malaria treatment.
Population pharmacokinetics in healthy adult volunteers and malaria-infected patients, both male and female, aged 15-65, following oral administration of the fixed-dose combination tablet.