.Pharmacolibrary.Drugs.ATC.P.P01BF08 .Pharmacolibrary.Drugs.ATC.P.P01BF08| name: | ArtemisininAndNaphthoquine | |
| ATC code: | P01BF08 | route: | oral |
| compartments: | 1 | |
| dosage: | 125 | mg |
| volume of distribution: | 11.5 | L |
| clearance: | 3.3 | L/h/kg |
| other parameters in model implementation | ||
Artemisinin and naphthoquine is a fixed-dose combination antimalarial drug, typically used for the treatment of uncomplicated Plasmodium falciparum malaria. Artemisinin is a fast-acting antimalarial agent derived from Artemisia annua with potent schizonticidal activity, while naphthoquine is a longer-acting 4-aminoquinoline antimalarial. The combination is used primarily in areas where multidrug-resistant malaria is prevalent. It is approved and used in some Asian and African countries.
Pharmacokinetic parameters from a study in adult and adolescent African patients with uncomplicated malaria following oral administration of artemisinin-naphthoquine combination. Parameters primarily refer to artemisinin component; naphthoquine parameters are rarely reported.