.Pharmacolibrary.Drugs.ATC.P.P02BA01

Information

Praziquantel is an anthelmintic agent primarily used to treat parasitic worm infections such as schistosomiasis and other fluke infestations. It is approved and widely used today for both human and veterinary medicine.

Pharmacokinetics

Adult healthy volunteers, after single oral administration.

References

1. Bonate, PL, et al., & Keiser, J (2018). Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale. Journal of pharmacokinetics and pharmacodynamics 45(5) 747–762. DOI:10.1007/s10928-018-9601-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30218416

2. Bustinduy, AL, et al., & Hope, WW (2020). Population Pharmacokinetics of Praziquantel in Pregnant and Lactating Filipino Women Infected with Schistosoma japonicum. Antimicrobial agents and chemotherapy 64(9) –. DOI:10.1128/AAC.00566-20 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32631820

3. Falcoz, C, et al., & Keiser, J (2022). R-praziquantel integrated population pharmacokinetics in preschool- and school-aged African children infected with Schistosoma mansoni and S. haematobium and Lao adults infected with Opisthorchis viverrini. Journal of pharmacokinetics and pharmacodynamics 49(3) 293–310. DOI:10.1007/s10928-021-09791-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35024995

Revisions

• 06/2025 initial generated model