modelR01AC02
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Levocabastine | |
| ATC code: | R01AC02 | route: | ocular |
| compartments: | 1 | |
| dosage: | 0.5 | mg |
| volume of distribution: | 0.54 | L |
| clearance: | 0.13 | L/h/kg |
| other parameters in model implementation | ||
Levocabastine is a selective second-generation antihistamine used primarily for the treatment of allergic conjunctivitis and rhinitis. It acts as a potent and selective H1 receptor antagonist and has been used in eye drops and nasal sprays for symptomatic relief of allergic reactions. Levocabastine is still marketed and approved in some countries, mostly in topical ocular or nasal formulations.
Pharmacokinetics
Pharmacokinetic parameters reported in healthy adult volunteers after a single 0.5 mg ocular (eye drop) dose.
References
Heykants, J, et al., & Woestenborghs, R (1995). The pharmacokinetic properties of topical levocabastine. A review. Clinical pharmacokinetics 29(4) 221–230. DOI:10.2165/00003088-199529040-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8549024
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)