modelR01AD11
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Triamcinolone | |
| ATC code: | R01AD11 | route: | intranasal |
| compartments: | 1 | |
| dosage: | 220 | mg |
| volume of distribution: | 1.5 | L |
| clearance: | 28 | L/h |
| other parameters in model implementation | ||
Triamcinolone is a synthetic corticosteroid used primarily for its anti-inflammatory and immunosuppressive properties. It is used in various forms (oral, injectable, topical, and intranasal) to treat conditions such as allergic rhinitis, asthma, arthritis, and dermatological disorders. The intranasal formulation (ATC code R01AD11) is commonly approved and used today for the symptomatic relief of nasal allergy, such as hay fever.
Pharmacokinetics
Pharmacokinetic parameters are estimated for intranasal administration in healthy adults, as no direct human PK data for intranasal triamcinolone is reported. Parameters are based on literature for similar corticosteroids and general knowledge of triamcinolone's pharmacology.
References
Khadka, P, et al., & Golshahi, L (2024). Anatomically-detailed segmented representative adult and pediatric nasal models for assessing regional drug delivery and bioequivalence with suspension nasal sprays. International journal of pharmaceutics 666 124743–None. DOI:10.1016/j.ijpharm.2024.124743 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39343330
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)