.Pharmacolibrary.Drugs.ATC.R.R02AA15 .Pharmacolibrary.Drugs.ATC.R.R02AA15| name: | PovidoneIodine |
| ATC code: | R02AA15 | route: | topical |
| n-compartments | 1 |
Povidone-iodine is a broad-spectrum antiseptic used for skin disinfection before and after surgery, as well as for the treatment and prevention of infections in wounds, burns, and mucous membranes. It is a complex of polyvinylpyrrolidone and iodine, which releases free iodine slowly, exerting bactericidal, fungicidal, and virucidal actions. It is administered topically and is not intended for systemic use. Povidone-iodine is approved and widely used as an antiseptic worldwide.
No pharmacokinetic model with quantitative parameters is available in the literature for systemic absorption of povidone-iodine used topically in healthy, adult subjects. Systemic bioavailability is generally considered negligible in intended topical use, except in rare cases such as deep wounds, burns, or oral administration, but even then PK modeling data are lacking.
Lin, YS, et al., & Milgrom, P (2018). Pharmacokinetics of Iodine and Fluoride following Application of an Anticaries Varnish in Adults. JDR clinical and translational research 3(3) 238–245. DOI:10.1177/2380084418771930 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30938600
Below, H, et al., & Rudolph, P (2006). Systemic iodine absorption after preoperative antisepsis using povidone-iodine in cataract surgery-- an open controlled study. Dermatology (Basel, Switzerland) 212 Suppl 1 41–46. DOI:10.1159/000089198 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16490974
Tahirović, H, et al., & Gnat, D (2009). Maternal and neonatal urinary iodine excretion and neonatal TSH in relation to use of antiseptic during caesarean section in an iodine sufficient area. Journal of pediatric endocrinology & metabolism : JPEM 22(12) 1145–1149. DOI:10.1515/jpem.2009.22.12.1145 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20333874