modelR02AA19
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Phenol | |
| ATC code: | R02AA19 | route: | topical |
| compartments: | 1 | |
| dosage: | 5 | mg |
| volume of distribution: | 0.7 | L |
| clearance: | 1.4 | L/h/kg |
| other parameters in model implementation | ||
Phenol is an aromatic organic compound historically used as an antiseptic, disinfectant, and local anesthetic for the relief of sore throat and minor mouth irritations. Its use as a medicinal agent is now limited due to toxicity concerns. Phenol is not widely approved for systemic administration today and its use in clinical medicine is mostly restricted to topical application or as a component in throat lozenges and sprays.
Pharmacokinetics
No modern publication with detailed human pharmacokinetic modeling or clinical PK parameters of phenol is available for ATC R02AA19 (throat preparations, human use). Data is scarce; parameterization below is an estimate based on historical and toxicological reports for healthy adults with topical/mucosal exposure.
References
Sun, HF, et al., & Li, D (2018). Chemical Peeling with a Modified Phenol Formula for the Treatment of Facial Freckles on Asian Skin. Aesthetic plastic surgery 42(2) 546–552. DOI:10.1007/s00266-017-1048-z PUBMED:https://pubmed.ncbi.nlm.nih.gov/29279953
Thelin, WR, et al., & Zoukhri, D (2012). Effect of topically applied epithelial sodium channel inhibitors on tear production in normal mice and in mice with induced aqueous tear deficiency. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 28(4) 433–438. DOI:10.1089/jop.2011.0157 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22455658
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)