name: | Flurbiprofen |
ATC code: | R02AX01 | route: | oral |
n-compartments | 2 |
Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory and antipyretic properties. It is used to treat symptoms of pain, inflammation, and fever, and is available as both systemic (oral) and local (lozenge, spray) formulations. Specifically, under the ATC code R02AX01, it is used for sore throat in lozenge or spray form, and is currently approved and in use in many countries.
Pharmacokinetic parameters reported for healthy adult volunteers after a single oral dose of flurbiprofen.
Qayyum, A, et al., & Farooqi, ZU (2011). Determination of pharmacokinetics of flurbiprofen in Pakistani population using modified HPLC method. Journal of chromatographic science 49(2) 108–113. DOI:10.1093/chrsci/49.2.108 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21223634
Lee, YJ, et al., & Lee, SY (2015). Effects of CYP2C9*1/*3 genotype on the pharmacokinetics of flurbiprofen in Korean subjects. Archives of pharmacal research 38(6) 1232–1237. DOI:10.1007/s12272-015-0580-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25712887
Kumpulainen, E, et al., & Kokki, H (2010). Plasma and cerebrospinal fluid pharmacokinetics of flurbiprofen in children. British journal of clinical pharmacology 70(4) 557–566. DOI:10.1111/j.1365-2125.2010.03720.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/20840447