modelR03BB01
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | IpratropiumBromide | |
| ATC code: | R03BB01 | route: | inhalation |
| compartments: | 1 | |
| dosage: | 40 | mg |
| volume of distribution: | 176 | L |
| clearance: | 2.3 | L/min |
| other parameters in model implementation | ||
Ipratropium bromide is an anticholinergic medication used as a bronchodilator for the relief of bronchospasm associated with chronic obstructive pulmonary disease (COPD) and asthma. It is administered via inhalation, approved and widely used for respiratory diseases.
Pharmacokinetics
Pharmacokinetic parameters reported in healthy adult volunteers following inhalation of ipratropium bromide.
References
Panning, CA, & DeBisschop, M (2003). Tiotropium: an inhaled, long-acting anticholinergic drug for chronic obstructive pulmonary disease. Pharmacotherapy 23(2) 183–189. DOI:10.1592/phco.23.2.183.32082 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12587807
MacGregor, TR, et al., & Wood, CC (2016). Efficiency of Ipratropium Bromide and Albuterol Deposition in the Lung Delivered via a Soft Mist Inhaler or Chlorofluorocarbon Metered-Dose Inhaler. Clinical and translational science 9(2) 105–113. DOI:10.1111/cts.12387 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26945929
Lee, YH, et al., & Noh, GJ (2016). Efficiency of a New Mesh-Type Nebulizer (NE-SM1 NEPLUS) for Intrapulmonary Delivery of Ipratropium Bromide in Surgical Patients. Basic & clinical pharmacology & toxicology 118(4) 313–319. DOI:10.1111/bcpt.12499 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26440415
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)