.Pharmacolibrary.Drugs.ATC.R.R03BB06

Information

Glycopyrronium bromide is a long-acting muscarinic antagonist (LAMA) used as a bronchodilator for the maintenance treatment of chronic obstructive pulmonary disease (COPD). It acts by inhibiting acetylcholine at muscarinic receptors in the airway smooth muscle, resulting in bronchodilation. It is approved and widely used today in inhalation form for COPD.

Pharmacokinetics

Pharmacokinetic parameters obtained from healthy adult subjects following single and multiple inhaled doses of glycopyrronium bromide (in the form of glycopyrronium bromide inhalation powder 50 mcg).

References

1. Kuna, P, et al., & Ciurlia, G (2022). Pharmacokinetics of extrafine beclometasone dipropionate/formoterol fumarate/glycopyrronium bromide in adolescent and adult patients with asthma. Pharmacology research & perspectives 10(4) e980–None. DOI:10.1002/prp2.980 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35733414

2. Bartels, C, et al., & Kaiser, G (2013). Determination of the pharmacokinetics of glycopyrronium in the lung using a population pharmacokinetic modelling approach. British journal of clinical pharmacology 76(6) 868–879. DOI:10.1111/bcp.12118 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23506208

3. Higashimori, M, et al., & Zhou, D (2021). Physiologically Based Pharmacokinetic Modelling of Glycopyrronium in Patients With Renal Impairment. Journal of pharmaceutical sciences 110(1) 438–445. DOI:10.1016/j.xphs.2020.03.014 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32240691

Revisions

• 06/2025 initial generated model