.Pharmacolibrary.Drugs.ATC.R.R05CB16

Information

name:Mannitol
ATC code:R05CB16
route:intravenous
n-compartments1

Mannitol is an osmotic diuretic used for the reduction of intracranial pressure and treatment of cerebral edema, as well as to promote diuresis in the prevention or treatment of acute renal failure. It is also used for diagnostic purposes in certain renal function tests. Mannitol is approved and used in clinical practice today.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers after a single intravenous dose.

References

  1. Deferm, N, et al., & Allegaert, K (2021). Glomerular Filtration Rate in Asphyxiated Neonates Under Therapeutic Whole-Body Hypothermia, Quantified by Mannitol Clearance. Clinical pharmacokinetics 60(7) 897–906. DOI:10.1007/s40262-021-00991-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33611729

  2. Hahn, RG (2023). Isotonic saline causes greater volume overload than electrolyte-free irrigating fluids. Journal of basic and clinical physiology and pharmacology 34(6) 717–723. DOI:10.1515/jbcpp-2021-0032 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34563101

  3. Kaneda, K, et al., & Todd, MM (2010). Pharmacokinetic characteristics of bolus-administered mannitol in patients undergoing elective craniotomy. Journal of clinical pharmacology 50(5) 536–543. DOI:10.1177/0091270009348973 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20051588

Revisions


Generated at 2025-07-21T18:21:10Z by OpenModelicaOpenModelica 1.25.1 using GenerateDoc.mos