.Pharmacolibrary.Drugs.ATC.R.R06AA02

Information

name:Diphenhydramine
ATC code:R06AA02
route:oral
n-compartments2

Diphenhydramine is a first-generation antihistamine with anticholinergic, antiemetic, and sedative properties. It is primarily used for the symptomatic relief of allergies, hay fever, common cold, insomnia, and as an antiemetic for motion sickness. It is approved and commonly used today as an over-the-counter medication.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers after a single oral administration.

References

  1. Luna, BG, et al., & Greenblatt, DJ (1989). Doxylamine and diphenhydramine pharmacokinetics in women on low-dose estrogen oral contraceptives. Journal of clinical pharmacology 29(3) 257–260. DOI:10.1002/j.1552-4604.1989.tb03323.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/2723113

  2. Spector, R, et al., & Ghoneim, MM (1980). Diphenhydramine in Orientals and Caucasians. Clinical pharmacology and therapeutics 28(2) 229–234. DOI:10.1038/clpt.1980.155 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7398190

  3. Paton, DM, & Webster, DR (1985). Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines). Clinical pharmacokinetics 10(6) 477–497. DOI:10.2165/00003088-198510060-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2866055

Revisions

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