.Pharmacolibrary.Drugs.ATC.R.R06AE07

Information

Cetirizine is a second-generation antihistamine used primarily for the treatment of allergic rhinitis and chronic urticaria. It is a selective antagonist of the peripheral H1 receptor and is approved for use globally.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers after a single oral 10 mg dose in fasting conditions.

References

1. Paine, SW, et al., & Hincks, PR (2022). Plasma and urine pharmacokinetics of hydroxyzine and cetirizine following repeated oral administrations to exercised horses. Journal of veterinary pharmacology and therapeutics 45(1) 46–53. DOI:10.1111/jvp.13010 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34469007

2. Knych, HK, et al., & McKemie, DS (2019). Pharmacokinetics of hydroxyzine and cetirizine following oral administration of hydroxyzine to exercised Thoroughbred horses. Journal of veterinary pharmacology and therapeutics 42(6) 617–623. DOI:10.1111/jvp.12808 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31490561

3. Hussein, Z, et al., & Stockis, A (2005). Retrospective population pharmacokinetics of levocetirizine in atopic children receiving cetirizine: the ETAC study. British journal of clinical pharmacology 59(1) 28–37. DOI:10.1111/j.1365-2125.2005.02242.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/15606437

Revisions

• 06/2025 initial generated model