.Pharmacolibrary.Drugs.ATC.R.R06AX25

Information

name:Mizolastine
ATC code:R06AX25
route:oral
n-compartments1

Mizolastine is a second-generation non-sedating antihistamine used to treat allergic rhinitis and urticaria. It works by selectively antagonizing peripheral H1 histamine receptors, reducing allergic symptoms. The drug is approved and used in several countries, though not available in the United States.

Pharmacokinetics

Pharmacokinetics in healthy adult volunteers after oral single-dose administration.

References

  1. Lebrun-Vignes, B, et al., & Chosidow, O (2001). Clinical pharmacokinetics of mizolastine. Clinical pharmacokinetics 40(7) 501–507. DOI:10.2165/00003088-200140070-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11510627

  2. Li, P, et al., & Zhang, GL (2018). Effects of UGT1A1, CYP3A5 and ABCB1 Genetic Variants on Pharmacokinetics of Antihistamine Drug Mizolastine in Chinese Healthy Volunteers. Basic & clinical pharmacology & toxicology 123(4) 464–473. DOI:10.1111/bcpt.13028 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29702735

  3. Simons, FE (2002). Comparative pharmacology of H1 antihistamines: clinical relevance. The American journal of medicine 113 Suppl 9A 38S–46S. DOI:10.1016/s0002-9343(02)01436-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12517581

Revisions


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