.Pharmacolibrary.Drugs.ATC.R.R07AX30 .Pharmacolibrary.Drugs.ATC.R.R07AX30| name: | IvacaftorAndLumacaftor |
| ATC code: | R07AX30 | route: | oral |
| n-compartments | 1 |
Ivacaftor and lumacaftor is a fixed-dose combination medication used to treat cystic fibrosis in patients with homozygous F508del mutation in the CFTR gene. Ivacaftor acts as a CFTR potentiator, while lumacaftor functions as a CFTR corrector. The combination is approved for use and marketed under the trade name Orkambi.
Pharmacokinetic parameters are reported for adult patients with cystic fibrosis, after repeated oral dosing of lumacaftor/ivacaftor combination (400 mg/250 mg) every 12 hours under fed conditions.