.Pharmacolibrary.Drugs.ATC.S.S01AE08 .Pharmacolibrary.Drugs.ATC.S.S01AE08| name: | Besifloxacin | |
| ATC code: | S01AE08 | route: | ophthalmic |
| compartments: | 1 | |
| dosage: | 1 | mg |
| volume of distribution: | 0.12 | L |
| clearance: | 0.08 | L/h/kg |
| other parameters in model implementation | ||
Besifloxacin is a fourth-generation fluoroquinolone antibiotic primarily used as an ophthalmic solution for the treatment of bacterial conjunctivitis. It is approved for topical ocular use and is known for its broad-spectrum antibacterial activity against gram-positive and gram-negative pathogens.
Pharmacokinetic parameters following topical ocular administration in healthy adults; limited systemic absorption due to administration route.
Chang, MH, & Fung, HB (2010). Besifloxacin: a topical fluoroquinolone for the treatment of bacterial conjunctivitis. Clinical therapeutics 32(3) 454–471. DOI:10.1016/j.clinthera.2010.03.013 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20399984
Segreti, J, et al., & Bertino, JS (2012). Challenges in assessing microbial susceptibility and predicting clinical response to newer-generation fluoroquinolones. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 28(1) 3–11. DOI:10.1089/jop.2011.0072 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21999341