.Pharmacolibrary.Drugs.ATC.S.S01EA01

Information

Epinephrine, also known as adrenaline, is a catecholamine used primarily in emergency medicine for the treatment of anaphylaxis, cardiac arrest, severe asthma attacks, and as a vasoconstrictor in local anesthesia. It is an approved and commonly used medication worldwide.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers after intravenous administration.

References

1. Eugene, AR (2016). A Clinical Trial Simulation Evaluating Epinephrine Pharmacokinetics at various Dosing Frequencies during Cardiopulmonary Resuscitation. MEDtube science 4(2) 8–15. PUBMED:https://pubmed.ncbi.nlm.nih.gov/28435854

2. Yoo, H, et al., & Jusko, WJ (2015). Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects. European journal of clinical pharmacology 71(10) 1197–1207. DOI:10.1007/s00228-015-1913-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26233335

3. Hoegberg, LC, et al., & Gosselin, S (2016). Systematic review of the effect of intravenous lipid emulsion therapy for local anesthetic toxicity. Clinical toxicology (Philadelphia, Pa.) 54(3) 167–193. DOI:10.3109/15563650.2015.1121270 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26853119

Revisions

• 06/2025 initial generated model