name: | Brimonidine |
ATC code: | S01EA05 | route: | ophthalmic |
n-compartments | 1 |
Brimonidine is an alpha-2 adrenergic receptor agonist primarily used in ophthalmology for the reduction of intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It is approved and widely used as an eye drop for this indication.
Pharmacokinetic parameters after topical ophthalmic administration of brimonidine in healthy adult subjects.
Ackerman, SL, et al., & Vittitow, JL (2019). Low-dose brimonidine for relief of ocular redness: integrated analysis of four clinical trials. Clinical & experimental optometry 102(2) 131–139. DOI:10.1111/cxo.12846 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30525235
Schnichels, S, et al., & Herrmann, A (2021). Improved Treatment Options for Glaucoma with Brimonidine-Loaded Lipid DNA Nanoparticles. ACS applied materials & interfaces 13(8) 9445–9456. DOI:10.1021/acsami.0c18626 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33528240
Kim, CY, et al., & Seong, GJ (2007). Brimonidine 0.2% versus brimonidine Purite 0.15% in Asian ocular hypertension. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 23(5) 481–486. DOI:10.1089/jop.2007.0042 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17900227