.Pharmacolibrary.Drugs.ATC.S.S01FB01

Information

name:Phenylephrine
ATC code:S01FB01
route:ophthalmic
n-compartments1

Phenylephrine is a selective alpha-1 adrenergic receptor agonist used as a decongestant, to increase blood pressure in hypotensive states, and as a mydriatic agent for ophthalmic use. In ophthalmology (ATC code S01FB01), it is topically applied to dilate the pupil for diagnostic or surgical procedures. It is approved and widely used in clinical practice.

Pharmacokinetics

Pharmacokinetic parameters for phenylephrine following topical ophthalmic administration in healthy adult volunteers.

References

  1. Atkinson, HC, et al., & Anderson, BJ (2015). Potential cardiovascular adverse events when phenylephrine is combined with paracetamol: simulation and narrative review. European journal of clinical pharmacology 71(8) 931–938. DOI:10.1007/s00228-015-1876-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26022219

  2. Seliniotaki, AK, et al., & Mataftsi, A (2022). Efficacy and safety of Mydriatic Microdrops for Retinopathy Of Prematurity Screening (MyMiROPS): study protocol for a non-inferiority crossover randomized controlled trial. Trials 23(1) 322–None. DOI:10.1186/s13063-022-06243-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35428316

  3. Wang, ES, & Hammarlund, ER (1970). Corneal absorption reinforcement of certain mydriatics. Journal of pharmaceutical sciences 59(11) 1559–1563. DOI:10.1002/jps.2600591103 PUBMED:https://pubmed.ncbi.nlm.nih.gov/5495477

Revisions


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