.Pharmacolibrary.Drugs.ATC.S.S01HA07

Information

Lidocaine is a local anesthetic and antiarrhythmic drug used to numb tissue in a specific area and to treat ventricular arrhythmias, especially after acute myocardial infarction. It is widely used in minor surgical procedures and certain ophthalmic applications. Lidocaine is approved and commonly used today.

Pharmacokinetics

Pharmacokinetic parameters derived from studies in healthy adult volunteers after intravenous administration.

References

1. Foong, KW, et al., & Loh, PS (2024). Population Pharmacokinetics of Intravenous Lidocaine in Adults: A Systematic Review. Clinical pharmacokinetics 63(5) 623–643. DOI:10.1007/s40262-024-01373-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38703307

2. Heath, C, et al., & Sommerfield, D (2023). Perioperative intravenous lidocaine use in children. Paediatric anaesthesia 33(5) 336–346. DOI:10.1111/pan.14608 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36424875

3. Crouch, CE, et al., & Fernandez-Bustamante, A (2023). Lidocaine Intraoperative Infusion Pharmacokinetics during Partial Hepatectomy for Living Liver Donation. Anesthesiology 138(1) 71–81. DOI:10.1097/ALN.0000000000004422 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36512707

Revisions

• 06/2025 initial generated model