.Pharmacolibrary.Drugs.ATC.S.S01XA18

Information

name:Ciclosporin
ATC code:S01XA18
route:topical
n-compartments1

Ciclosporin (also known as cyclosporine) is a calcineurin inhibitor immunosuppressant used to prevent organ transplant rejection, and to treat certain autoimmune diseases. It is clinically approved and in use today, including topical ophthalmic formulations (ATC S01XA18) for conditions such as dry eye disease.

Pharmacokinetics

Pharmacokinetic parameters in adults after ophthalmic (eye drop) administration; limited systemic absorption expected.

References

  1. Surber, C, et al., & Büchner, S (1992). Clinical controversy on the effect of topical ciclosporin: what is the target site?. Dermatology (Basel, Switzerland) 185(4) 242–245. DOI:10.1159/000247460 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1477416

  2. Frampton, JE, & Blair, HA (2018). Dupilumab: A Review in Moderate-to-Severe Atopic Dermatitis. American journal of clinical dermatology 19(4) 617–624. DOI:10.1007/s40257-018-0370-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30027349

Revisions

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