.Pharmacolibrary.Drugs.ATC.V.V03AB15

Information

name:Naloxone
ATC code:V03AB15
route:intravenous
n-compartments2

Naloxone is a non-selective and competitive opioid receptor antagonist used to rapidly reverse opioid overdose and opioid-induced respiratory depression. It is approved for use in emergency settings by various routes including intravenous, intramuscular, subcutaneous, and intranasal administration.

Pharmacokinetics

Pharmacokinetic parameters derived from healthy adult volunteers following intravenous administration.

References

  1. Saari, TI, et al., & Dale, O (2024). Clinical Pharmacokinetics and Pharmacodynamics of Naloxone. Clinical pharmacokinetics 63(4) 397–422. DOI:10.1007/s40262-024-01355-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38485851

  2. Dowling, J, et al., & Graudins, A (2008). Population pharmacokinetics of intravenous, intramuscular, and intranasal naloxone in human volunteers. Therapeutic drug monitoring 30(4) 490–496. DOI:10.1097/FTD.0b013e3181816214 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18641540

  3. Robinson, A, & Wermeling, DP (2014). Intranasal naloxone administration for treatment of opioid overdose. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 71(24) 2129–2135. DOI:10.2146/ajhp130798 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25465584

Revisions

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