.Pharmacolibrary.Drugs.ATC.V.V03AB23

Information

Acetylcysteine is a mucolytic agent and an antidote used primarily for the treatment of acetaminophen (paracetamol) overdose. It restores hepatic glutathione and protects against liver damage. It is also used to reduce the viscosity of pulmonary secretions in diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis. The drug is approved and in current clinical use, both as oral and intravenous formulations.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult subjects following intravenous administration.

References

1. Forrest, JA, et al., & Prescott, LF (1982). Clinical pharmacokinetics of paracetamol. Clinical pharmacokinetics 7(2) 93–107. DOI:10.2165/00003088-198207020-00001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7039926

2. Anderson, SM, et al., & Patel, RV (2011). Intravenous N-acetylcysteine in the prevention of contrast media-induced nephropathy. The Annals of pharmacotherapy 45(1) 101–107. DOI:10.1345/aph.1P275 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21205947

3. Fayed, MS, et al., & Coles, LD (2023). Population Pharmacokinetic Model of N-Acetylcysteine During Periods of Recurrent Hypoglycemia in Healthy Volunteers. Clinical pharmacology in drug development 12(12) 1234–1240. DOI:10.1002/cpdd.1338 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37937383

Revisions

• 06/2025 initial generated model