.Pharmacolibrary.Drugs.ATC.V.V03AB23_1 .Pharmacolibrary.Drugs.ATC.V.V03AB23_1| name: | Acetylcysteine_1 |
| ATC code: | V03AB23_1 | route: | oral |
| n-compartments | 1 |
Acetylcysteine is a mucolytic agent and an antidote used primarily for the treatment of acetaminophen (paracetamol) overdose. It restores hepatic glutathione and protects against liver damage. It is also used to reduce the viscosity of pulmonary secretions in diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis. The drug is approved and in current clinical use, both as oral and intravenous formulations.
Pharmacokinetic parameters in healthy adults following oral administration.
Forrest, JA, et al., & Prescott, LF (1982). Clinical pharmacokinetics of paracetamol. Clinical pharmacokinetics 7(2) 93–107. DOI:10.2165/00003088-198207020-00001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7039926
Aggarwal, R, et al., & Chauhan, MK (2020). Treatment and management strategies of onychomycosis. Journal de mycologie medicale 30(2) 100949–None. DOI:10.1016/j.mycmed.2020.100949 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32234349
Petkova, T, et al., & Milanova, A (2022). Population Pharmacokinetics of Doxycycline, Administered Alone or with N-Acetylcysteine, in Chickens with Experimental . Pharmaceutics 14(11) –. DOI:10.3390/pharmaceutics14112440 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36432632