name: | Flumazenil |
ATC code: | V03AB25 | route: | intravenous |
n-compartments | 2 |
Flumazenil is an imidazobenzodiazepine derivative used as a selective benzodiazepine receptor antagonist. It is primarily used for the reversal of benzodiazepine sedation during anesthesia and for the management of benzodiazepine overdose. Flumazenil is approved for clinical use and acts rapidly to counteract the central effects of benzodiazepines.
Pharmacokinetic data reported for healthy adult volunteers following intravenous administration of flumazenil.
Rousseau-Blass, F, et al., & Pang, DS (2021). A Pharmacokinetic-Pharmacodynamic Study of Intravenous Midazolam and Flumazenil in Adult New Zealand White-Californian Rabbits (. Journal of the American Association for Laboratory Animal Science : JAALAS 60(3) 319–328. DOI:10.30802/AALAS-JAALAS-20-000084 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33673881
Karavokiros, KA, & Tsipis, GB (1990). Flumazenil: a benzodiazepine antagonist. DICP : the annals of pharmacotherapy 24(10) 976–981. DOI:10.1177/106002809002401013 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2244412
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