.Pharmacolibrary.Drugs.ATC.V.V03AB26

Information

name:Methionine
ATC code:V03AB26
route:oral
n-compartments1

Methionine is an essential amino acid used as a nutritional supplement and an antidote for acetaminophen poisoning. It is involved in the synthesis of proteins and other important molecules and acts as a methyl group donor in various biochemical processes. The drug is approved for clinical use primarily as a nutritional supplement and as a protective agent in cases of acetaminophen toxicity.

Pharmacokinetics

Estimated pharmacokinetic parameters for healthy adults, based on known amino acid pharmacokinetics and published indirect references; explicit PK data for methionine as a drug are not found in primary literature.

References

  1. Forrest, JA, et al., & Prescott, LF (1982). Clinical pharmacokinetics of paracetamol. Clinical pharmacokinetics 7(2) 93–107. DOI:10.2165/00003088-198207020-00001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7039926

  2. Shabana, S, et al., & Liu, C (2022). Multifunctional nanoparticles based on marine polysaccharides for apremilast delivery to inflammatory macrophages: Preparation, targeting ability, and uptake mechanism. International journal of biological macromolecules 222(Pt B) 1709–1722. DOI:10.1016/j.ijbiomac.2022.09.225 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36179875

  3. Buus, S, et al., & Keiding, S (2006). Individual radiation response of parotid glands investigated by dynamic 11C-methionine PET. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 78(3) 262–269. DOI:10.1016/j.radonc.2006.02.013 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16545879

Revisions


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