.Pharmacolibrary.Drugs.ATC.V.V03AB29

Information

Cholinesterase is an enzyme that catalyzes the hydrolysis of acetylcholine and other choline esters. As a drug term, 'cholinesterase' typically refers to treatments involving exogenous administration of the enzyme as a detoxifying or antidotal agent in cases of organophosphate or carbamate poisoning. It is not a medication used in routine therapy and does not have broad clinical use currently. The ATC code V03AB29 refers to preparations of cholinesterase used as antidotes.

Pharmacokinetics

No published pharmacokinetic parameters for exogenously administered cholinesterase in humans were identified; values are unreported and not estimable from existing literature.

References

1. Gomolin, IH, et al., & Jeitner, TM (2011). Cholinesterase inhibitors: applying pharmacokinetics to clinical decision making. The American journal of geriatric pharmacotherapy 9(4) 259–263. DOI:10.1016/j.amjopharm.2011.06.001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21763214

2. Defilippi, JL, & Crismon, ML (2003). Drug interactions with cholinesterase inhibitors. Drugs & aging 20(6) 437–444. DOI:10.2165/00002512-200320060-00003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12710863

3. Farlow, MR (2003). Clinical pharmacokinetics of galantamine. Clinical pharmacokinetics 42(15) 1383–1392. DOI:10.2165/00003088-200342150-00005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/14674789

Revisions

• 06/2025 initial generated model