.Pharmacolibrary.Drugs.ATC.V.V03AC02 .Pharmacolibrary.Drugs.ATC.V.V03AC02| name: | Deferiprone |
| ATC code: | V03AC02 | route: | oral |
| n-compartments | 1 |
Deferiprone is an oral iron chelator primarily used for the treatment of iron overload in patients with thalassemia major and other chronic anemias, especially when standard chelation therapy is inadequate or contraindicated. It is approved and in use for this indication.
Pharmacokinetic parameters reported from studies in adult patients (both sexes) with thalassemia major receiving oral deferiprone under steady-state conditions.
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Soulières, D, et al., & Tricta, F (2022). The pharmacokinetic and safety profile of single-dose deferiprone in subjects with sickle cell disease. Annals of hematology 101(3) 533–539. DOI:10.1007/s00277-021-04728-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34981144
Bellanti, F, et al., & Della Pasqua, O (2016). Sampling Optimization in Pharmacokinetic Bridging Studies: Example of the Use of Deferiprone in Children With β-Thalassemia. Journal of clinical pharmacology 56(9) 1094–1103. DOI:10.1002/jcph.708 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26785826