.Pharmacolibrary.Drugs.ATC.V.V03AF02 .Pharmacolibrary.Drugs.ATC.V.V03AF02| name: | Dexrazoxane |
| ATC code: | V03AF02 | route: | intravenous |
| n-compartments | 2 |
Dexrazoxane is a cytoprotective agent used to reduce the incidence and severity of cardiotoxicity associated with anthracycline chemotherapy such as doxorubicin. It acts as a chelating agent, reducing free radical formation and preventing cardiac tissue damage. Dexrazoxane is approved for use in patients receiving high cumulative doses of anthracyclines.
Pharmacokinetic parameters obtained from adult cancer patients receiving intravenous dexrazoxane before anthracycline chemotherapy.
Cvetković, RS, & Scott, LJ (2005). Dexrazoxane : a review of its use for cardioprotection during anthracycline chemotherapy. Drugs 65(7) 1005–1024. DOI:10.2165/00003495-200565070-00008 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15892593