.Pharmacolibrary.Drugs.ATC.V.V03AF03 .Pharmacolibrary.Drugs.ATC.V.V03AF03| name: | CalciumFolinate | |
| ATC code: | V03AF03 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 25 | mg |
| volume of distribution: | 7.2 | L |
| clearance: | 205 | ml/min |
| other parameters in model implementation | ||
Calcium folinate (leucovorin calcium) is a medication used to reduce the toxic effects of folic acid antagonists such as methotrexate. It is also used in combination with 5-fluorouracil in the treatment of colorectal cancer. Calcium folinate is approved and widely used today as a rescue agent in chemotherapy protocols.
Pharmacokinetic parameters reported in healthy adult volunteers after intravenous administration.