.Pharmacolibrary.Drugs.ATC.V.V03AF04 .Pharmacolibrary.Drugs.ATC.V.V03AF04| name: | CalciumLevofolinate | |
| ATC code: | V03AF04 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 100 | mg |
| volume of distribution: | 10 | L |
| clearance: | 250 | mL/min |
| other parameters in model implementation | ||
Calcium levofolinate (also known as levoleucovorin) is the active (L) isomer of folinic acid, used as an adjuvant to enhance the efficacy and reduce the toxicity of methotrexate and as a rescue agent in certain chemotherapy regimens. It is also used in combination with 5-fluorouracil for colorectal cancer therapy. It is approved and in clinical use.
Estimated pharmacokinetic parameters for a typical healthy adult patient, as no direct published pharmacokinetic study on calcium levofolinate was found. Parameters were inferred from studies of racemic folinic acid/leucovorin.