modelV04CE01
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Galactose | |
| ATC code: | V04CE01 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 400 | mg |
| volume of distribution: | 0.35 | L |
| clearance: | 60 | ml/min/kg |
| other parameters in model implementation | ||
Galactose is a monosaccharide sugar, part of the lactose disaccharide found in milk. It is used rarely as a diagnostic agent for liver function and galactose metabolism disorders, but is not an approved medication for therapeutic use in most countries today.
Pharmacokinetics
Estimated pharmacokinetic parameters for adult healthy individuals. No definitive PK profile reported in literature for therapeutic use; estimates derived based on monosaccharide similarities and diagnostic use.
References
Mion, F, et al., & Minaire, Y (1999). [13C]-Galactose breath test: correlation with liver fibrosis in chronic hepatitis C. European journal of clinical investigation 29(7) 624–629. DOI:10.1046/j.1365-2362.1999.00512.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/10411669
Joffe, P, et al., & Sidhu, J (1998). Single-dose pharmacokinetics of citalopram in patients with moderate renal insufficiency or hepatic cirrhosis compared with healthy subjects. European journal of clinical pharmacology 54(3) 237–242. DOI:10.1007/s002280050452 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9681666
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)