modelV04CX01
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | IndocyanineGreen | |
| ATC code: | V04CX01 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 25 | mg |
| volume of distribution: | 0.16 | L |
| clearance: | 9.3 | mL/min/kg |
| other parameters in model implementation | ||
Indocyanine green (ICG) is a water-soluble, tricarbocyanine dye used medically as a diagnostic agent for assessing hepatic function, liver blood flow, and cardiac output. Upon intravenous injection, it binds rapidly to plasma proteins and is exclusively eliminated by hepatic parenchymal cells into the bile, without undergoing enterohepatic recirculation. Indocyanine green has widespread approval and is routinely used in clinical practice worldwide.
Pharmacokinetics
Pharmacokinetic parameters reported for healthy adult volunteers of both sexes after intravenous injection.
References
Carpenter, GW, et al., & O'Neal, DP (2018). Closed-Loop Intravenous Drug Administration Using Photoplethysmography. IEEE journal of translational engineering in health and medicine 6 4300108–None. DOI:10.1109/JTEHM.2018.2879090 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30519516
Saito, M, et al., & Takusagawa, S (2024). Population Pharmacokinetic Modeling and Simulation of Pudexacianinium (ASP5354) for Dose Setting of a Phase 2 First-in-Patient Study: A Novel Imaging Agent for Intraoperative Ureter Visualization during Abdominopelvic Surgery. Clinical pharmacology in drug development 13(5) 454–464. DOI:10.1002/cpdd.1354 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38135485
Sim, DA, et al., & Fruttiger, M (2015). A simple method for in vivo labelling of infiltrating leukocytes in the mouse retina using indocyanine green dye. Disease models & mechanisms 8(11) 1479–1487. DOI:10.1242/dmm.019018 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26398933
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)