.Pharmacolibrary.Drugs.ATC.V.V04CX04

Information

name:Mannitol
ATC code:V04CX04
route:intravenous
n-compartments1

Mannitol is an osmotic diuretic used to reduce intracranial and intraocular pressure and to promote diuresis in various clinical situations. It is approved and commonly used in hospital settings, particularly for treating cerebral edema, acute renal failure prevention, and high intraocular pressure.

Pharmacokinetics

Pharmacokinetic parameters are reported for healthy adults after intravenous administration.

References

  1. Deferm, N, et al., & Allegaert, K (2021). Glomerular Filtration Rate in Asphyxiated Neonates Under Therapeutic Whole-Body Hypothermia, Quantified by Mannitol Clearance. Clinical pharmacokinetics 60(7) 897–906. DOI:10.1007/s40262-021-00991-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33611729

  2. Hahn, RG (2023). Isotonic saline causes greater volume overload than electrolyte-free irrigating fluids. Journal of basic and clinical physiology and pharmacology 34(6) 717–723. DOI:10.1515/jbcpp-2021-0032 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34563101

  3. Kaneda, K, et al., & Todd, MM (2010). Pharmacokinetic characteristics of bolus-administered mannitol in patients undergoing elective craniotomy. Journal of clinical pharmacology 50(5) 536–543. DOI:10.1177/0091270009348973 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20051588

Revisions


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