modelV04CX04
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Mannitol | |
| ATC code: | V04CX04 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 100 | mg |
| volume of distribution: | 0.23 | L |
| clearance: | 64 | ml/min |
| other parameters in model implementation | ||
Mannitol is an osmotic diuretic used to reduce intracranial and intraocular pressure and to promote diuresis in various clinical situations. It is approved and commonly used in hospital settings, particularly for treating cerebral edema, acute renal failure prevention, and high intraocular pressure.
Pharmacokinetics
Pharmacokinetic parameters are reported for healthy adults after intravenous administration.
References
Deferm, N, et al., & Allegaert, K (2021). Glomerular Filtration Rate in Asphyxiated Neonates Under Therapeutic Whole-Body Hypothermia, Quantified by Mannitol Clearance. Clinical pharmacokinetics 60(7) 897–906. DOI:10.1007/s40262-021-00991-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33611729
Hahn, RG (2023). Isotonic saline causes greater volume overload than electrolyte-free irrigating fluids. Journal of basic and clinical physiology and pharmacology 34(6) 717–723. DOI:10.1515/jbcpp-2021-0032 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34563101
Kaneda, K, et al., & Todd, MM (2010). Pharmacokinetic characteristics of bolus-administered mannitol in patients undergoing elective craniotomy. Journal of clinical pharmacology 50(5) 536–543. DOI:10.1177/0091270009348973 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20051588
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)