.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A01A_StomatologicalPreparations.A01AC03_Hydrocortisone.Hydrocortisone

Information

Hydrocortisone is a synthetic corticosteroid used primarily for its anti-inflammatory and immunosuppressive effects. It is employed in the treatment of conditions such as adrenal insufficiency, severe allergies, skin diseases, and as a topical agent in oral preparations for inflammation in the mouth. It is an approved and widely used medication.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers following oral administration.

References

1. Hamitouche, N, et al., & Laviolle, B (2017). Population Pharmacokinetic-Pharmacodynamic Model of Oral Fludrocortisone and Intravenous Hydrocortisone in Healthy Volunteers. The AAPS journal 19(3) 727–735. DOI:10.1208/s12248-016-0041-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28083797

2. Werumeus Buning, J, et al., & van Beek, AP (2017). Pharmacokinetics of oral hydrocortisone - Results and implications from a randomized controlled trial. Metabolism: clinical and experimental 71 7–16. DOI:10.1016/j.metabol.2017.02.005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28521880

3. Polito, A, et al., & Alvarez, JC (2016). Pharmacokinetics of oral fludrocortisone in septic shock. British journal of clinical pharmacology 82(6) 1509–1516. DOI:10.1111/bcp.13065 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27416887

Revisions

• 06/2025 initial generated model