.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A01A_StomatologicalPreparations.A01AC04_Prednisolone.Prednisolone_1

Information

Prednisolone is a synthetic glucocorticoid and anti-inflammatory agent widely used in the treatment of a variety of conditions including asthma, rheumatoid arthritis, autoimmune disorders, inflammatory diseases, and allergies. It is an active metabolite of prednisone and is approved and in common clinical use today.

Pharmacokinetics

Pharmacokinetic model for intravenous administration in healthy adults.

References

1. Petersen, KB, et al., & Schmiegelow, K (2003). Population pharmacokinetics of prednisolone in children with acute lymphoblastic leukemia. Cancer chemotherapy and pharmacology 51(6) 465–473. DOI:10.1007/s00280-003-0602-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12698270

2. Honoré, PM, et al., & Spapen, HD (2014). What do we know about steroids metabolism and 'PK/PD approach' in AKI and CKD especially while on RRT--current status in 2014. Blood purification 38(2) 154–157. DOI:10.1159/000368390 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25471548

3. Hill, MR, et al., & Brenner, AM (1990). Monitoring glucocorticoid therapy: a pharmacokinetic approach. Clinical pharmacology and therapeutics 48(4) 390–398. DOI:10.1038/clpt.1990.167 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2225699

Revisions

• 06/2025 initial generated model