.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A02B_DrugsForPepticUlcerAndGastroOesophagealRefluxDis.A02BC01_Omeprazole.Omeprazole

Information

Omeprazole is a proton pump inhibitor (PPI) that suppresses gastric acid secretion by inhibiting the H+/K+ ATPase enzyme in the parietal cells of the stomach. It is widely used for the treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger-Ellison syndrome. It is approved and commonly prescribed globally.

Pharmacokinetics

Pharmacokinetics in healthy adult volunteers after a single oral dose of 20 mg omeprazole.

References

1. Chen, K, et al., & Pei, Q (2022). Effect of Laparoscopic Sleeve Gastrectomy on the Pharmacokinetics of Oral Omeprazole Using a Population Approach. Pharmaceutics 14(10) –. DOI:10.3390/pharmaceutics14101986 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36297422

2. Ala, S, et al., & Shiran, MR (2013). Population pharmacokinetics of omeprazole in a random Iranian population. Caspian journal of internal medicine 4(3) 712–716. PUBMED:https://pubmed.ncbi.nlm.nih.gov/24009966

3. Noubarani, M, et al., & Keyhanfar, F (2012). Variation in omeprazole pharmacokinetics in a random Iranian population: a pilot study. Biopharmaceutics & drug disposition 33(6) 324–331. DOI:10.1002/bdd.1805 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22890488

Revisions

• 06/2025 initial generated model