.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A02B_DrugsForPepticUlcerAndGastroOesophagealRefluxDis.A02BD11_PantoprazoleAmoxicillinC.PantoprazoleAmoxicillinC .Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A02B_DrugsForPepticUlcerAndGastroOesophagealRefluxDis.A02BD11_PantoprazoleAmoxicillinC.PantoprazoleAmoxicillinC| name: | PantoprazoleAmoxicillinClarithromycinAndMetronidazole |
| ATC code: | A02BD11 | route: | oral |
| n-compartments | 1 |
A fixed-combination regimen used in eradication of Helicobacter pylori infection. It contains pantoprazole (proton pump inhibitor), amoxicillin (penicillin-antibiotic), clarithromycin (macrolide-antibiotic), and metronidazole (nitroimidazole-antibiotic). These are combined to suppress gastric acid and provide broad-spectrum antibacterial action. The combination is used as first-line therapy in several clinical guidelines.
No experimental pharmacokinetic (PK) model for the fixed four-drug combination was identified; parameters herein are estimated based on representative oral PK profiles from literature for each drug in healthy adults.