name: | Atropine_1 |
ATC code: | A03BA01_1 | route: | oral |
n-compartments | 2 |
Atropine is an antimuscarinic (anticholinergic) drug that blocks the actions of acetylcholine at muscarinic receptors. It is primarily used to treat bradycardia (slow heart rate), as a premedication for anesthesia to reduce salivation, to reverse cholinergic poisoning (from organophosphates or nerve agents), and to dilate pupils in ophthalmology. Atropine is widely approved and used today in various clinical settings.
Healthy adults after oral administration, single dose.
Gervais, HW, et al., & Dick, WF (1997). Plasma concentration following oral and intramuscular atropine in children and their clinical effects. Paediatric anaesthesia 7(1) 13–18. DOI:10.1046/j.1460-9592.1997.d01-40.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/9041569
Schep, LJ, et al., & Mégarbane, B (2012). The clinical toxicology of γ-hydroxybutyrate, γ-butyrolactone and 1,4-butanediol. Clinical toxicology (Philadelphia, Pa.) 50(6) 458–470. DOI:10.3109/15563650.2012.702218 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22746383
Kersten, H, et al., & Molden, E (2014). Association between inherited CYP2D6/2C19 phenotypes and anticholinergic measures in elderly patients using anticholinergic drugs. Therapeutic drug monitoring 36(1) 125–130. DOI:10.1097/FTD.0b013e31829da990 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24089073