.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A06A_DrugsForConstipation.A06AD02_MagnesiumOxide.MagnesiumOxide

Information

name:MagnesiumOxide
ATC code:A06AD02
route:oral
n-compartments1

Magnesium oxide is an inorganic compound used as a dietary supplement in individuals with magnesium deficiency, and as an antacid and laxative. It is commonly employed for short-term relief of heartburn, dyspepsia, and constipation. Magnesium oxide remains in use and is approved in multiple countries for these indications.

Pharmacokinetics

Estimated oral pharmacokinetic parameters for healthy adults. No published source with detailed compartmental PK parameters; magnesium oxide is poorly absorbed when administered orally and acts primarily in the gastrointestinal tract.

References

  1. Kashihara, Y, et al., & Ieiri, I (2019). Effects of magnesium oxide on pharmacokinetics of L-dopa/carbidopa and assessment of pharmacodynamic changes by a model-based simulation. European journal of clinical pharmacology 75(3) 351–361. DOI:10.1007/s00228-018-2568-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30382297

  2. Hoy, SM, et al., & Wagstaff, AJ (2009). Sodium picosulfate/magnesium citrate: a review of its use as a colorectal cleanser. Drugs 69(1) 123–136. DOI:10.2165/00003495-200969010-00009 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19192941

  3. Schuette, SA, et al., & Janghorbani, M (1994). Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection. JPEN. Journal of parenteral and enteral nutrition 18(5) 430–435. DOI:10.1177/0148607194018005430 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7815675

Revisions


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