.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A06A_DrugsForConstipation.A06AD04_MagnesiumSulfate.MagnesiumSulfate .Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A06A_DrugsForConstipation.A06AD04_MagnesiumSulfate.MagnesiumSulfate| name: | MagnesiumSulfate |
| ATC code: | A06AD04 | route: | intravenous |
| n-compartments | 2 |
Magnesium sulfate is an inorganic salt used in medicine for a variety of indications. It is primarily used intravenously for the prevention and treatment of seizures in pre-eclampsia and eclampsia, as well as in the management of hypomagnesemia and torsades de pointes. It is also administered orally as a laxative. Magnesium sulfate is an approved and widely used medication in current clinical practice.
Pharmacokinetics reported for adult pregnant women with pre-eclampsia, following intravenous administration. Population pharmacokinetic study.
da Costa, TX, et al., & Oliveira, AG (2020). Population Pharmacokinetics of Magnesium Sulfate in Preeclampsia and Associated Factors. Drugs in R&D 20(3) 257–266. DOI:10.1007/s40268-020-00315-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32642964
Brookfield, KF, et al., & Carvalho, B (2016). Pharmacokinetics and placental transfer of magnesium sulfate in pregnant women. American journal of obstetrics and gynecology 214(6) 737.e1–737.e7379. DOI:10.1016/j.ajog.2015.12.060 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26767791
Rower, JE, et al., & Finkelstein, Y (2025). Pharmacokinetics and Pharmacodynamics of Intravenous Magnesium Sulfate in Pediatric Acute Asthma Exacerbations. Journal of clinical pharmacology 65(6) 665–674. DOI:10.1002/jcph.6179 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39775569