.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A06A_DrugsForConstipation.A06AD17_SodiumPhosphate.SodiumPhosphate

Information

Sodium phosphate is an osmotic laxative used primarily to cleanse the bowel prior to colonoscopy or other diagnostic procedures. The drug is used for the treatment of constipation and for bowel preparation. Its use is generally approved, but oral sodium phosphate products have been associated with rare but serious nephrotoxicity and electrolyte disturbances.

Pharmacokinetics

Pharmacokinetic parameters estimated for healthy adult individuals based on general pharmacokinetic knowledge for similar orally administered phosphate salts. No specific published PK models are available for sodium phosphate with the requested granularity.

References

1. Wen, J, et al., & Gonzalez, D (2024). Pharmacokinetics of Dexamethasone in Children and Adolescents with Obesity. Journal of clinical pharmacology 64(12) 1491–1504. DOI:10.1002/jcph.6108 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39120865

2. Hoy, SM, et al., & Wagstaff, AJ (2009). Sodium picosulfate/magnesium citrate: a review of its use as a colorectal cleanser. Drugs 69(1) 123–136. DOI:10.2165/00003495-200969010-00009 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19192941

3. Sampathkumar, K (2009). Niacin and analogs for phosphate control in dialysis--perspective from a developing country. International urology and nephrology 41(4) 913–918. DOI:10.1007/s11255-008-9497-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19037739

Revisions

• 06/2025 initial generated model