.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A06A_DrugsForConstipation.A06AD61_LactuloseCombinations.LactuloseCombinations

Information

Lactulose is a synthetic disaccharide used primarily for the treatment of constipation and hepatic encephalopathy. In combination products, it can be formulated with other agents to enhance its laxative properties or treat related conditions. Lactulose is considered safe and is approved for use in many countries today.

Pharmacokinetics

Pharmacokinetic parameters are estimated for healthy adults as no direct human PK publication is available for lactulose, combinations.

References

1. Mouly, S, et al., & Urien, S (2001). Increased oral ganciclovir bioavailability in HIV-infected patients with chronic diarrhoea and wasting syndrome--a population pharmacokinetic study. British journal of clinical pharmacology 51(6) 557–565. DOI:10.1046/j.0306-5251.2001.01389.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/11422015

2. Maxton, DG, et al., & Menzies, IS (1990). Combined assessment of intestinal disaccharidases in congenital asucrasia by differential urinary disaccharide excretion. Journal of clinical pathology 43(5) 406–409. DOI:10.1136/jcp.43.5.406 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2370309

Revisions

• 06/2025 initial generated model